Summary | |
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Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF05724 Thiopurine S-methyltransferase (TPMT) |
Function |
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. |
Biological Process |
GO:0032259 methylation |
Molecular Function |
GO:0008119 thiopurine S-methyltransferase activity GO:0008168 methyltransferase activity GO:0008172 S-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups |
Cellular Component | - |
KEGG |
hsa00983 Drug metabolism - other enzymes |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-1430728: Metabolism R-HSA-156581: Methylation R-HSA-156580: Phase II conjugation |
Summary | |
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Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TPMT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TPMT in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TPMT in various data sets.
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Points in the above scatter plot represent the mutation difference of TPMT in various data sets.
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Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TPMT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TPMT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TPMT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TPMT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TPMT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TPMT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TPMT |
Name | thiopurine S-methyltransferase |
Aliases | S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TPMT collected from DrugBank database. |
Details on drugs targeting TPMT.
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