Summary | |
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Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lysosome Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Domain |
PF09286 Pro-kumamolisin |
Function |
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). |
Biological Process |
GO:0001894 tissue homeostasis GO:0006986 response to unfolded protein GO:0007033 vacuole organization GO:0007040 lysosome organization GO:0030968 endoplasmic reticulum unfolded protein response GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response GO:0043171 peptide catabolic process GO:0045453 bone resorption GO:0046849 bone remodeling GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0060249 anatomical structure homeostasis GO:0080171 lytic vacuole organization GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0008238 exopeptidase activity GO:0008240 tripeptidyl-peptidase activity GO:0017171 serine hydrolase activity GO:0033218 amide binding GO:0042277 peptide binding |
Cellular Component |
GO:0005775 vacuolar lumen GO:0042470 melanosome GO:0043202 lysosomal lumen GO:0048770 pigment granule |
KEGG |
hsa04142 Lysosome |
Reactome |
R-HSA-381070: IRE1alpha activates chaperones R-HSA-392499: Metabolism of proteins R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-381038: XBP1(S) activates chaperone genes |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TPP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TPP1 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TPP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TPP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TPP1 in various data sets.
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Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TPP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TPP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TPP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TPP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TPP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TPP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TPP1 |
Name | tripeptidyl peptidase I |
Aliases | TPP I; CLN2; SCAR7; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); spinoce ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TPP1 collected from DrugBank database. |
There is no record. |