Summary | |
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Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain | - |
Function |
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. |
Biological Process |
GO:0006477 protein sulfation GO:0006478 peptidyl-tyrosine sulfation GO:0006790 sulfur compound metabolic process GO:0018212 peptidyl-tyrosine modification GO:0051923 sulfation |
Molecular Function |
GO:0008146 sulfotransferase activity GO:0008476 protein-tyrosine sulfotransferase activity GO:0016782 transferase activity, transferring sulfur-containing groups |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TPST2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TPST2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TPST2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TPST2 in various data sets.
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Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TPST2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TPST2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TPST2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TPST2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TPST2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TPST2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TPST2 |
Name | tyrosylprotein sulfotransferase 2 |
Aliases | TANGO13B; transport and golgi organization 13 homolog B (Drosophila); TPST-2; transport and golgi organizati ...... |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TPST2 collected from DrugBank database. |
There is no record. |