Browse TPT1

Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF00838 Translationally controlled tumour protein
Function

Involved in calcium binding and microtubule stabilization.

> Gene Ontology
 
Biological Process GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009615 response to virus
GO:0055074 calcium ion homeostasis
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902532 negative regulation of intracellular signal transduction
GO:2001020 regulation of response to DNA damage stimulus
GO:2001021 negative regulation of response to DNA damage stimulus
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0008017 microtubule binding
GO:0015631 tubulin binding
Cellular Component GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0045298 tubulin complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TPT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TPT1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TPT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6540.0141
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3030.943
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.9070.771
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0430.931
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5950.85
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8530.836
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3580.598
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5690.857
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1580.965
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5290.888
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3680.95
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3548.23e-05
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TPT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TPT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TPT1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TPT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TPT1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TPT1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTPT1
Nametumor protein, translationally-controlled 1
Aliases TCTP; fortilin; HRF; p02; histamine-releasing factor; Translationally-controlled tumor protein
Chromosomal Location13q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TPT1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TPT1.
ID Name Drug Type Targets #Targets
DB11093Calcium CitrateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29
DB11348Calcium PhosphateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29