Summary | |
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Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16673 TNF receptor-associated factor BIRC3 binding domain |
Function |
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. |
Biological Process |
GO:0001959 regulation of cytokine-mediated signaling pathway GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0060759 regulation of response to cytokine stimulus GO:0071356 cellular response to tumor necrosis factor GO:0097191 extrinsic apoptotic signaling pathway GO:2001233 regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0031625 ubiquitin protein ligase binding GO:0031996 thioesterase binding GO:0032813 tumor necrosis factor receptor superfamily binding GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component | - |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04210 Apoptosis hsa04668 TNF signaling pathway |
Reactome |
R-HSA-73887: Death Receptor Signalling R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-162582: Signal Transduction R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRAF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRAF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRAF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRAF1 in various data sets.
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Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRAF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRAF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRAF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRAF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRAF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRAF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRAF1 |
Name | TNF receptor-associated factor 1 |
Aliases | EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6 |
Chromosomal Location | 9q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRAF1 collected from DrugBank database. |
There is no record. |