Browse TRAF1

Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF16673 TNF receptor-associated factor BIRC3 binding domain
Function

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

> Gene Ontology
 
Biological Process GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060759 regulation of response to cytokine stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001233 regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Molecular Function GO:0005126 cytokine receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0044389 ubiquitin-like protein ligase binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04064 NF-kappa B signaling pathway
hsa04210 Apoptosis
hsa04668 TNF signaling pathway
Reactome R-HSA-73887: Death Receptor Signalling
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-162582: Signal Transduction
R-HSA-75893: TNF signaling
R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRAF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRAF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRAF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3870.45
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0440.977
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6910.498
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0250.952
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0910.96
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.180.942
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5260.29
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2360.866
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.930.523
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0990.356
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9990.561
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2380.107
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRAF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRAF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRAF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRAF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRAF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRAF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRAF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRAF1
NameTNF receptor-associated factor 1
Aliases EBI6; MGC:10353; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6
Chromosomal Location9q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRAF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.