Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF16673 TNF receptor-associated factor BIRC3 binding domain PF00097 Zinc finger PF02176 TRAF-type zinc finger |
Function |
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. |
Biological Process |
GO:0000209 protein polyubiquitination GO:0000302 response to reactive oxygen species GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002250 adaptive immune response GO:0002367 cytokine production involved in immune response GO:0002369 T cell cytokine production GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002637 regulation of immunoglobulin production GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002724 regulation of T cell cytokine production GO:0002726 positive regulation of T cell cytokine production GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0007252 I-kappaB phosphorylation GO:0007254 JNK cascade GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009306 protein secretion GO:0010035 response to inorganic substance GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0010939 regulation of necrotic cell death GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0031098 stress-activated protein kinase signaling cascade GO:0032092 positive regulation of protein binding GO:0032147 activation of protein kinase activity GO:0032623 interleukin-2 production GO:0032663 regulation of interleukin-2 production GO:0032743 positive regulation of interleukin-2 production GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034349 glial cell apoptotic process GO:0034350 regulation of glial cell apoptotic process GO:0034351 negative regulation of glial cell apoptotic process GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0034976 response to endoplasmic reticulum stress GO:0038061 NIK/NF-kappaB signaling GO:0042110 T cell activation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043393 regulation of protein binding GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043496 regulation of protein homodimerization activity GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0048305 immunoglobulin secretion GO:0050708 regulation of protein secretion GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051023 regulation of immunoglobulin secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization GO:0051403 stress-activated MAPK cascade GO:0051865 protein autoubiquitination GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070206 protein trimerization GO:0070207 protein homotrimerization GO:0070265 necrotic cell death GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070534 protein K63-linked ubiquitination GO:0070997 neuron death GO:0071241 cellular response to inorganic substance GO:0071356 cellular response to tumor necrosis factor GO:0071550 death-inducing signaling complex assembly GO:0071593 lymphocyte aggregation GO:0071731 response to nitric oxide GO:0071732 cellular response to nitric oxide GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090073 positive regulation of protein homodimerization activity GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097300 programmed necrotic cell death GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902170 cellular response to reactive nitrogen species GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903719 regulation of I-kappaB phosphorylation GO:1903721 positive regulation of I-kappaB phosphorylation GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0005174 CD40 receptor binding GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0031435 mitogen-activated protein kinase kinase kinase binding GO:0031625 ubiquitin protein ligase binding GO:0031996 thioesterase binding GO:0032813 tumor necrosis factor receptor superfamily binding GO:0044389 ubiquitin-like protein ligase binding GO:0046625 sphingolipid binding |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0005938 cell cortex GO:0009898 cytoplasmic side of plasma membrane GO:0035631 CD40 receptor complex GO:0043235 receptor complex GO:0045121 membrane raft GO:0097057 TRAF2-GSTP1 complex GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain GO:0099568 cytoplasmic region GO:1990597 AIP1-IRE1 complex GO:1990604 IRE1-TRAF2-ASK1 complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04064 NF-kappa B signaling pathway hsa04071 Sphingolipid signaling pathway hsa04141 Protein processing in endoplasmic reticulum hsa04210 Apoptosis hsa04380 Osteoclast differentiation hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04668 TNF signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-109581: Apoptosis R-HSA-5218900: CASP8 activity is inhibited R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-73887: Death Receptor Signalling R-HSA-5688426: Deubiquitination R-HSA-69416: Dimerization of procaspase-8 R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-140534: Ligand-dependent caspase activation R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5357801: Programmed Cell Death R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-5213460: RIPK1-mediated regulated necrosis R-HSA-5218859: Regulated Necrosis R-HSA-3371378: Regulation by c-FLIP R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-5675482: Regulation of necroptotic cell death R-HSA-162582: Signal Transduction R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway R-HSA-5357786: TNFR1-induced proapoptotic signaling R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-933541: TRAF6 mediated IRF7 activation R-HSA-933542: TRAF6 mediated NF-kB activation R-HSA-5689880: Ub-specific processing proteases |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRAF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TRAF2 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TRAF2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRAF2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TRAF2 in various data sets.
|
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRAF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRAF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRAF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRAF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRAF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRAF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRAF2 |
Name | TNF receptor-associated factor 2 |
Aliases | TRAP3; MGC:45012; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protei ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRAF2 collected from DrugBank database. |
There is no record. |