Summary | |
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Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria. |
Domain |
PF04849 HAP1 N-terminal conserved region PF12448 Kinesin associated protein |
Function |
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. |
Biological Process |
GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0008333 endosome to lysosome transport GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016197 endosomal transport GO:0043413 macromolecule glycosylation GO:0070085 glycosylation |
Molecular Function |
GO:0050811 GABA receptor binding |
Cellular Component |
GO:0005769 early endosome |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions |
Summary | |
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Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRAK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRAK1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRAK1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRAK1 in various data sets.
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Summary | |
---|---|
Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRAK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRAK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRAK1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRAK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRAK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRAK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRAK1 |
Name | trafficking protein, kinesin binding 1 |
Aliases | OIP106; KIAA1042; MILT1; OGT(O Glc NAc transferase) interacting protein 106 KDa; O-linked N-acetylglucosamin ...... |
Chromosomal Location | 3p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRAK1 collected from DrugBank database. |
There is no record. |