TISIDB

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	NA
Domain	-
Function	NA

> Gene Ontology [ TOP ]
Biological Process	-
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TRD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

Literatures describing the relation between TRD and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
23295945	leukemia	Promote immunity	CD19(+) leukemia xenografts in mice were reduced with CAR(+)γδ T cells compared with control mice. Polyclonal CAR(+)γδ T cells were functional when TCRγδ and CAR were stimulated and displayed enhanced killing of CD19(+) tumor cell lines compared with CAR(neg)γδ T cells.

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

Statistical results of TRD in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders [ TOP ]
There is no record.

> Mutation difference between responders and non-responders [ TOP ]
There is no record.

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRD. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TRD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TRD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TRD
Name	T cell receptor delta locus
Aliases	TCRDV1; TRD@; TCRDV1@; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C)
Chromosomal Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TRD collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.