Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Secreted ; SUBCELLULAR LOCATION: Isoform 3: Secreted |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. |
Biological Process |
GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002521 leukocyte differentiation GO:0002577 regulation of antigen processing and presentation GO:0002579 positive regulation of antigen processing and presentation GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002582 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002583 regulation of antigen processing and presentation of peptide antigen GO:0002585 positive regulation of antigen processing and presentation of peptide antigen GO:0002586 regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0006959 humoral immune response GO:0007009 plasma membrane organization GO:0009595 detection of biotic stimulus GO:0010324 membrane invagination GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019722 calcium-mediated signaling GO:0019882 antigen processing and presentation GO:0019932 second-messenger-mediated signaling GO:0023035 CD40 signaling pathway GO:0032490 detection of molecule of bacterial origin GO:0032494 response to peptidoglycan GO:0032496 response to lipopolysaccharide GO:0032497 detection of lipopolysaccharide GO:0032499 detection of peptidoglycan GO:0038118 C-C chemokine receptor CCR7 signaling pathway GO:0043410 positive regulation of MAPK cascade GO:0048002 antigen processing and presentation of peptide antigen GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050848 regulation of calcium-mediated signaling GO:0050850 positive regulation of calcium-mediated signaling GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0070098 chemokine-mediated signaling pathway GO:0070099 regulation of chemokine-mediated signaling pathway GO:0070101 positive regulation of chemokine-mediated signaling pathway GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070391 response to lipoteichoic acid GO:0070392 detection of lipoteichoic acid GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071223 cellular response to lipoteichoic acid GO:0071224 cellular response to peptidoglycan GO:0071417 cellular response to organonitrogen compound GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0097028 dendritic cell differentiation GO:0098581 detection of external biotic stimulus GO:0099024 plasma membrane invagination GO:1903076 regulation of protein localization to plasma membrane GO:1903078 positive regulation of protein localization to plasma membrane GO:1903080 regulation of C-C chemokine receptor CCR7 signaling pathway GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway GO:1903729 regulation of plasma membrane organization GO:1903829 positive regulation of cellular protein localization GO:1904375 regulation of protein localization to cell periphery GO:1904377 positive regulation of protein localization to cell periphery GO:1990778 protein localization to cell periphery GO:2000348 regulation of CD40 signaling pathway GO:2000350 positive regulation of CD40 signaling pathway |
Molecular Function |
GO:0001530 lipopolysaccharide binding GO:0005539 glycosaminoglycan binding GO:0042834 peptidoglycan binding GO:0070891 lipoteichoic acid binding GO:0097110 scaffold protein binding |
Cellular Component | - |
KEGG |
hsa04380 Osteoclast differentiation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System R-HSA-416700: Other semaphorin interactions R-HSA-373755: Semaphorin interactions |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TREM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TREM2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TREM2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TREM2 in various data sets.
|
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TREM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TREM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TREM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TREM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TREM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TREM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TREM2 |
Name | triggering receptor expressed on myeloid cells 2 |
Aliases | TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TREM2 collected from DrugBank database. |
There is no record. |