Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. |
Domain | - |
Function |
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04623 Cytosolic DNA-sensing pathway |
Reactome |
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-3270619: IRF3-mediated induction of type I IFN R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-3248023: Regulation by TREX1 R-HSA-3134975: Regulation of innate immune responses to cytosolic DNA R-HSA-1834941: STING mediated induction of host immune responses |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TREX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TREX1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TREX1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TREX1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TREX1 in various data sets.
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Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TREX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TREX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TREX1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TREX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TREX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TREX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TREX1 |
Name | three prime repair exonuclease 1 |
Aliases | DRN3; Aicardi-Goutieres syndrome 1; CRV; HERNS; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III; ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TREX1 collected from DrugBank database. |
There is no record. |