Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Domain |
PF11838 ERAP1-like C-terminal domain PF01433 Peptidase family M1 |
Function |
Specific inactivation of TRH after its release. |
Biological Process |
GO:0003013 circulatory system process GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0043171 peptide catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004177 aminopeptidase activity GO:0008235 metalloexopeptidase activity GO:0008237 metallopeptidase activity GO:0008238 exopeptidase activity GO:0033218 amide binding GO:0042277 peptide binding GO:0070006 metalloaminopeptidase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRHDE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TRHDE in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRHDE in various data sets.
|
Points in the above scatter plot represent the mutation difference of TRHDE in various data sets.
|
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRHDE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRHDE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRHDE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRHDE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRHDE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRHDE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRHDE |
Name | thyrotropin-releasing hormone degrading enzyme |
Aliases | PGPEP2; TRH-DE; pyroglutamyl-peptidase II; pyroglutamyl aminopeptidase II; TRH-specific aminopeptidase; TRH- ...... |
Chromosomal Location | 12q15-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRHDE collected from DrugBank database. |
There is no record. |