Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, P-body |
Domain |
PF00630 Filamin/ABP280 repeat PF01436 NHL repeat PF00643 B-box zinc finger |
Function |
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). |
Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0006417 regulation of translation GO:0008543 fibroblast growth factor receptor signaling pathway GO:0010586 miRNA metabolic process GO:0010608 posttranscriptional regulation of gene expression GO:0014020 primary neural tube formation GO:0016331 morphogenesis of embryonic epithelium GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017148 negative regulation of translation GO:0021915 neural tube development GO:0031047 gene silencing by RNA GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0035148 tube formation GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035239 tube morphogenesis GO:0035278 miRNA mediated inhibition of translation GO:0040029 regulation of gene expression, epigenetic GO:0040033 negative regulation of translation, ncRNA-mediated GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045974 regulation of translation, ncRNA-mediated GO:0050779 RNA destabilization GO:0051865 protein autoubiquitination GO:0060147 regulation of posttranscriptional gene silencing GO:0060148 positive regulation of posttranscriptional gene silencing GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060964 regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0061157 mRNA destabilization GO:0061158 3'-UTR-mediated mRNA destabilization GO:0061351 neural precursor cell proliferation GO:0071774 response to fibroblast growth factor GO:0072089 stem cell proliferation GO:0072175 epithelial tube formation GO:2000177 regulation of neural precursor cell proliferation GO:2000637 positive regulation of gene silencing by miRNA |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0030371 translation repressor activity GO:0035198 miRNA binding GO:0045182 translation regulator activity GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component |
GO:0000932 cytoplasmic mRNA processing body GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRIM71 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRIM71 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRIM71 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRIM71 in various data sets.
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Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRIM71. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRIM71. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRIM71. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRIM71. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRIM71 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRIM71 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TRIM71 |
Name | tripartite motif containing 71, E3 ubiquitin protein ligase |
Aliases | LIN41; LIN-41; tripartite motif-containing 71; tripartite motif containing 71; abnormal cell LINeage LIN-41; ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRIM71 collected from DrugBank database. |
There is no record. |