Summary | |
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Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF00520 Ion transport protein PF08344 Transient receptor ion channel II |
Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. |
Biological Process |
GO:0000041 transition metal ion transport GO:0003013 circulatory system process GO:0003015 heart process GO:0006582 melanin metabolic process GO:0006816 calcium ion transport GO:0006828 manganese ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010522 regulation of calcium ion transport into cytosol GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010959 regulation of metal ion transport GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0043270 positive regulation of ion transport GO:0044057 regulation of system process GO:0044550 secondary metabolite biosynthetic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051480 regulation of cytosolic calcium ion concentration GO:0051592 response to calcium ion GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0055074 calcium ion homeostasis GO:0060047 heart contraction GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0061337 cardiac conduction GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0090279 regulation of calcium ion import GO:0090280 positive regulation of calcium ion import GO:0097553 calcium ion transmembrane import into cytosol GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902656 calcium ion import into cytosol GO:1903169 regulation of calcium ion transmembrane transport GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:1904062 regulation of cation transmembrane transport GO:1904064 positive regulation of cation transmembrane transport GO:1904427 positive regulation of calcium ion transmembrane transport GO:2000021 regulation of ion homeostasis |
Molecular Function |
GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015279 store-operated calcium channel activity GO:0022803 passive transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0043178 alcohol binding GO:0046873 metal ion transmembrane transporter activity GO:0070679 inositol 1,4,5 trisphosphate binding GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0043235 receptor complex |
KEGG |
hsa04360 Axon guidance hsa04724 Glutamatergic synapse hsa04726 Serotonergic synapse hsa04972 Pancreatic secretion |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-422475: Axon guidance R-HSA-5576891: Cardiac conduction R-HSA-1266738: Developmental Biology R-HSA-168256: Immune System R-HSA-983712: Ion channel transport R-HSA-5578775: Ion homeostasis R-HSA-397014: Muscle contraction R-HSA-373752: Netrin-1 signaling R-HSA-418890: Role of second messengers in netrin-1 signaling R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-2672351: Stimuli-sensing channels R-HSA-3295583: TRP channels R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRPC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRPC1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRPC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRPC1 in various data sets.
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Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRPC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRPC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRPC1 |
Name | transient receptor potential cation channel, subfamily C, member 1 |
Aliases | HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRPC1 collected from DrugBank database. |
There is no record. |