Summary | |
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Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF12796 Ankyrin repeats (3 copies) PF00520 Ion transport protein PF08344 Transient receptor ion channel II |
Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. |
Biological Process |
GO:0000041 transition metal ion transport GO:0000302 response to reactive oxygen species GO:0001666 response to hypoxia GO:0006816 calcium ion transport GO:0006828 manganese ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006979 response to oxidative stress GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007338 single fertilization GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009566 fertilization GO:0010035 response to inorganic substance GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0010959 regulation of metal ion transport GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016358 dendrite development GO:0018107 peptidyl-threonine phosphorylation GO:0018210 peptidyl-threonine modification GO:0022604 regulation of cell morphogenesis GO:0022898 regulation of transmembrane transporter activity GO:0030168 platelet activation GO:0031345 negative regulation of cell projection organization GO:0032409 regulation of transporter activity GO:0032411 positive regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032414 positive regulation of ion transmembrane transporter activity GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042542 response to hydrogen peroxide GO:0043270 positive regulation of ion transport GO:0045665 negative regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050774 negative regulation of dendrite morphogenesis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051480 regulation of cytosolic calcium ion concentration GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0055074 calcium ion homeostasis GO:0070301 cellular response to hydrogen peroxide GO:0070482 response to oxygen levels GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:2000171 negative regulation of dendrite development |
Molecular Function |
GO:0003779 actin binding GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015279 store-operated calcium channel activity GO:0022803 passive transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0030276 clathrin binding GO:0042805 actinin binding GO:0043178 alcohol binding GO:0046873 metal ion transmembrane transporter activity GO:0051117 ATPase binding GO:0070679 inositol 1,4,5 trisphosphate binding GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0036056 filtration diaphragm GO:0036057 slit diaphragm |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04360 Axon guidance |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-114508: Effects of PIP2 hydrolysis R-HSA-139853: Elevation of cytosolic Ca2+ levels R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-983712: Ion channel transport R-HSA-373752: Netrin-1 signaling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-418360: Platelet calcium homeostasis R-HSA-418346: Platelet homeostasis R-HSA-418890: Role of second messengers in netrin-1 signaling R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-2672351: Stimuli-sensing channels R-HSA-3295583: TRP channels R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRPC6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRPC6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRPC6 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRPC6 in various data sets.
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Summary | |
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Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPC6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPC6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPC6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPC6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRPC6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRPC6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRPC6 |
Name | transient receptor potential cation channel, subfamily C, member 6 |
Aliases | TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ...... |
Chromosomal Location | 11q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRPC6 collected from DrugBank database. |
There is no record. |