Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF02816 Alpha-kinase family PF00520 Ion transport protein PF16519 Tetramerisation domain of TRPM |
Function |
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). |
Biological Process |
GO:0006816 calcium ion transport GO:0006875 cellular metal ion homeostasis GO:0007160 cell-matrix adhesion GO:0010960 magnesium ion homeostasis GO:0010961 cellular magnesium ion homeostasis GO:0016340 calcium-dependent cell-matrix adhesion GO:0031032 actomyosin structure organization GO:0031589 cell-substrate adhesion GO:0046777 protein autophosphorylation GO:0051259 protein oligomerization GO:0051262 protein tetramerization GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0097300 programmed necrotic cell death |
Molecular Function |
GO:0003779 actin binding GO:0004674 protein serine/threonine kinase activity GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0017022 myosin binding GO:0022803 passive transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0001726 ruffle GO:0031252 cell leading edge |
KEGG |
hsa04621 NOD-like receptor signaling pathway hsa04978 Mineral absorption |
Reactome |
R-HSA-983712: Ion channel transport R-HSA-2672351: Stimuli-sensing channels R-HSA-3295583: TRP channels R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRPM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRPM7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRPM7 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRPM7 in various data sets.
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Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPM7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRPM7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRPM7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TRPM7 |
Name | transient receptor potential cation channel, subfamily M, member 7 |
Aliases | CHAK1; LTRPC7; TRP-PLIK; ALSPDC; CHAK; LTrpC-7; LTRPC ion channel family member 7; channel-kinase 1; long tr ...... |
Chromosomal Location | 15q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRPM7 collected from DrugBank database. |
Details on drugs targeting TRPM7.
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