Browse TRPM8

Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells.
Domain PF00520 Ion transport protein
Function

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

> Gene Ontology
 
Biological Process GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0016048 detection of temperature stimulus
GO:0050951 sensory perception of temperature stimulus
GO:0050955 thermoception
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0055074 calcium ion homeostasis
GO:0070206 protein trimerization
GO:0070207 protein homotrimerization
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
Molecular Function GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0009897 external side of plasma membrane
GO:0045121 membrane raft
GO:0098552 side of membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04750 Inflammatory mediator regulation of TRP channels
Reactome R-HSA-983712: Ion channel transport
R-HSA-2672351: Stimuli-sensing channels
R-HSA-3295583: TRP channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRPM8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRPM8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRPM8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5650.417
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7140.554
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4390.639
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.280.65
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6950.586
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2330.861
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1480.203
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3220.805
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11123.0250.0209
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6510.601
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3150.844
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1720.536
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRPM8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.52.715.80.0147
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.51.716.80.0108
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.511.8-2.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPM8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPM8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPM8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPM8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRPM8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRPM8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRPM8
Nametransient receptor potential cation channel, subfamily M, member 8
Aliases LTRPC6; TRPP8; LTrpC-6; long transient receptor potential channel 6; short form of the TRPM8 cationic channe ......
Chromosomal Location2q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRPM8 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TRPM8.
ID Name Drug Type Targets #Targets
DB00825MentholSmall MoleculeOPRK1, TRPA1, TRPM8, TRPV34
DB09061CannabidiolSmall MoleculeCACNA1G, CACNA1H, CACNA1I, CHRNA7, CNR1, CNR2, GLRA1, GLRA1, GLRA3 ......25