Browse TRPS1

Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00320 GATA zinc finger
Function

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0002062 chondrocyte differentiation
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007507 heart development
GO:0017038 protein import
GO:0032330 regulation of chondrocyte differentiation
GO:0034504 protein localization to nucleus
GO:0044744 protein targeting to nucleus
GO:0045165 cell fate commitment
GO:0048565 digestive tract development
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0055123 digestive system development
GO:0061035 regulation of cartilage development
GO:0061448 connective tissue development
GO:1902593 single-organism nuclear import
Molecular Function GO:0001085 RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0008134 transcription factor binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005667 transcription factor complex
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRPS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8030.0363
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.260.116
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4710.482
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1020.827
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1290.957
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0580.986
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.240.577
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0490.97
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4230.772
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1330.876
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7250.517
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2790.115
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRPS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRPS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRPS1
Nametrichorhinophalangeal syndrome I
Aliases GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ......
Chromosomal Location8q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRPS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.