Summary | |
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Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00320 GATA zinc finger |
Function |
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. |
Biological Process |
GO:0001501 skeletal system development GO:0002062 chondrocyte differentiation GO:0006606 protein import into nucleus GO:0006607 NLS-bearing protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007507 heart development GO:0017038 protein import GO:0032330 regulation of chondrocyte differentiation GO:0034504 protein localization to nucleus GO:0044744 protein targeting to nucleus GO:0045165 cell fate commitment GO:0048565 digestive tract development GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051216 cartilage development GO:0055123 digestive system development GO:0061035 regulation of cartilage development GO:0061448 connective tissue development GO:1902593 single-organism nuclear import |
Molecular Function |
GO:0001085 RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0008134 transcription factor binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TRPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TRPS1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TRPS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TRPS1 in various data sets.
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Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TRPS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TRPS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TRPS1 |
Name | trichorhinophalangeal syndrome I |
Aliases | GC79; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; Zinc finger transcription f ...... |
Chromosomal Location | 8q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TRPS1 collected from DrugBank database. |
There is no record. |