Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. |
Domain |
PF11864 Domain of unknown function (DUF3384) PF02145 Rap/ran-GAP PF03542 Tuberin |
Function |
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). |
Biological Process |
GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007050 cell cycle arrest GO:0007507 heart development GO:0008286 insulin receptor signaling pathway GO:0014020 primary neural tube formation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0017038 protein import GO:0021915 neural tube development GO:0030100 regulation of endocytosis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032007 negative regulation of TOR signaling GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033673 negative regulation of kinase activity GO:0034504 protein localization to nucleus GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0042326 negative regulation of phosphorylation GO:0043434 response to peptide hormone GO:0043491 protein kinase B signaling GO:0044744 protein targeting to nucleus GO:0045786 negative regulation of cell cycle GO:0046626 regulation of insulin receptor signaling pathway GO:0046627 negative regulation of insulin receptor signaling pathway GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0050918 positive chemotaxis GO:0051056 regulation of small GTPase mediated signal transduction GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051348 negative regulation of transferase activity GO:0051896 regulation of protein kinase B signaling GO:0051898 negative regulation of protein kinase B signaling GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060627 regulation of vesicle-mediated transport GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0072175 epithelial tube formation GO:0198738 cell-cell signaling by wnt GO:1900076 regulation of cellular response to insulin stimulus GO:1900077 negative regulation of cellular response to insulin stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0019902 phosphatase binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0033596 TSC1-TSC2 complex GO:0044445 cytosolic part |
KEGG |
hsa04115 p53 signaling pathway hsa04140 Regulation of autophagy hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04910 Insulin signaling pathway hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-198323: AKT phosphorylates targets in the cytosol R-HSA-1280218: Adaptive Immune System R-HSA-2262752: Cellular responses to stress R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-180292: GAB1 signalosome R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-165181: Inhibition of TSC complex formation by PKB R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-1632852: Macroautophagy R-HSA-199991: Membrane Trafficking R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-109703: PKB-mediated events R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-74752: Signaling by Insulin receptor R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-8854214: TBC/RABGAPs R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-5653656: Vesicle-mediated transport R-HSA-165159: mTOR signalling |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TSC2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSC2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TSC2 in various data sets.
|
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSC2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TSC2 |
Name | tuberous sclerosis 2 |
Aliases | tuberin; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberous sclerosis 2 protein |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSC2 collected from DrugBank database. |
There is no record. |