Summary | |
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Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). |
Biological Process |
GO:0003002 regionalization GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0009952 anterior/posterior pattern specification GO:0042471 ear morphogenesis GO:0042474 middle ear morphogenesis GO:0043583 ear development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0060021 palate development GO:0060023 soft palate development GO:0090596 sensory organ morphogenesis |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSHZ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TSHZ1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSHZ1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TSHZ1 in various data sets.
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Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSHZ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSHZ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSHZ1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSHZ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSHZ1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSHZ1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TSHZ1 |
Name | teashirt zinc finger homeobox 1 |
Aliases | NY-CO-33; SDCCAG33; serologically defined colon cancer antigen 33; teashirt zinc finger 1; teashirt family z ...... |
Chromosomal Location | 18q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSHZ1 collected from DrugBank database. |
There is no record. |