Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cell projection, growth cone Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. |
Domain | - |
Function |
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). |
Biological Process |
GO:0002087 regulation of respiratory gaseous exchange by neurological system process GO:0003016 respiratory system process GO:0007585 respiratory gaseous exchange GO:0043576 regulation of respiratory gaseous exchange GO:0044057 regulation of system process GO:0044065 regulation of respiratory system process |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding |
Cellular Component |
GO:0030426 growth cone GO:0030427 site of polarized growth |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSHZ3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TSHZ3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSHZ3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TSHZ3 in various data sets.
|
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSHZ3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSHZ3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSHZ3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSHZ3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSHZ3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSHZ3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TSHZ3 |
Name | teashirt zinc finger homeobox 3 |
Aliases | KIAA1474; TSH3; teashirt 3; ZNF537; zinc finger protein 537; teashirt family zinc finger 3; Teashirt homolog ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSHZ3 collected from DrugBank database. |
There is no record. |