Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Late endosome membrane |
Domain |
PF00335 Tetraspanin family |
Function |
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. |
Biological Process |
GO:0007009 plasma membrane organization GO:0051604 protein maturation GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1990778 protein localization to cell periphery |
Molecular Function | - |
Cellular Component |
GO:0097197 tetraspanin-enriched microdomain |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSPAN15 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TSPAN15 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSPAN15 in various data sets.
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Points in the above scatter plot represent the mutation difference of TSPAN15 in various data sets.
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Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSPAN15. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSPAN15. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSPAN15. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSPAN15. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSPAN15 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSPAN15 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TSPAN15 |
Name | tetraspanin 15 |
Aliases | NET-7; TM4SF15; transmembrane 4 superfamily member 15; 2700063A19Rik; tetraspan NET-7; transmembrane 4 super ...... |
Chromosomal Location | 10q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSPAN15 collected from DrugBank database. |
There is no record. |