Summary | |
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Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00956 Nucleosome assembly protein (NAP) |
Function |
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0009314 response to radiation GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031497 chromatin assembly GO:0034728 nucleosome organization GO:0043491 protein kinase B signaling GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071480 cellular response to gamma radiation GO:0071824 protein-DNA complex subunit organization GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSPYL5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TSPYL5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSPYL5 in various data sets.
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Points in the above scatter plot represent the mutation difference of TSPYL5 in various data sets.
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Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSPYL5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSPYL5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSPYL5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSPYL5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSPYL5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TSPYL5 |
Name | TSPY-like 5 |
Aliases | KIAA1750; TSPY-like protein 5; Testis-specific Y-encoded-like protein 5 |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSPYL5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |