Browse TSR1

Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleolus
Domain PF08142 AARP2CN (NUC121) domain
PF04950 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
Function

Required during maturation of the 40S ribosomal subunit in the nucleolus.

> Gene Ontology
 
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000469 cleavage involved in rRNA processing
GO:0000478 endonucleolytic cleavage involved in rRNA processing
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0016072 rRNA metabolic process
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0030490 maturation of SSU-rRNA
GO:0034470 ncRNA processing
GO:0042254 ribosome biogenesis
GO:0042255 ribosome assembly
GO:0042274 ribosomal small subunit biogenesis
GO:0071826 ribonucleoprotein complex subunit organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0030515 snoRNA binding
GO:0032561 guanyl ribonucleotide binding
GO:0034511 U3 snoRNA binding
Cellular Component GO:0030684 preribosome
GO:0030688 preribosome, small subunit precursor
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312: rRNA processing
R-HSA-8868773: rRNA processing in the nucleus and cytosol
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TSR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.67 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TSR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2140.312
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2210.894
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2020.88
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3460.298
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2760.899
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.440.879
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0190.956
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0280.986
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1110.947
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0870.947
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3270.863
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0770.194
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TSR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TSR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TSR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTSR1
NameTSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
Aliases FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TSR1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.