Summary | |
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Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus |
Domain |
PF08142 AARP2CN (NUC121) domain PF04950 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal |
Function |
Required during maturation of the 40S ribosomal subunit in the nucleolus. |
Biological Process |
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000469 cleavage involved in rRNA processing GO:0000478 endonucleolytic cleavage involved in rRNA processing GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006364 rRNA processing GO:0016072 rRNA metabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0030490 maturation of SSU-rRNA GO:0034470 ncRNA processing GO:0042254 ribosome biogenesis GO:0042255 ribosome assembly GO:0042274 ribosomal small subunit biogenesis GO:0071826 ribonucleoprotein complex subunit organization GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090501 RNA phosphodiester bond hydrolysis GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0030515 snoRNA binding GO:0032561 guanyl ribonucleotide binding GO:0034511 U3 snoRNA binding |
Cellular Component |
GO:0030684 preribosome GO:0030688 preribosome, small subunit precursor |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72312: rRNA processing R-HSA-8868773: rRNA processing in the nucleus and cytosol |
Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TSR1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TSR1 in various data sets.
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Summary | |
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Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TSR1 |
Name | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
Aliases | FLJ10534; TSR1, 20S rRNA accumulation, homolog (yeast); Pre-rRNA-processing protein TSR1 homolog |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSR1 collected from DrugBank database. |
There is no record. |