Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. |
Domain |
PF00069 Protein kinase domain |
Function |
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. |
Biological Process |
GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0022412 cellular process involved in reproduction in multicellular organism GO:0046777 protein autophosphorylation GO:0048232 male gamete generation GO:0048515 spermatid differentiation |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004674 protein serine/threonine kinase activity |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0005813 centrosome GO:0005814 centriole GO:0030141 secretory granule GO:0044450 microtubule organizing center part GO:0097223 sperm part GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TSSK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TSSK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TSSK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of TSSK2 in various data sets.
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Summary | |
---|---|
Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TSSK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TSSK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TSSK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TSSK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TSSK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TSSK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TSSK2 |
Name | testis-specific serine kinase 2 |
Aliases | SPOGA2; FLJ38613; STK22B; serine/threonine kinase 22B (spermiogenesis associated); DGS-G; TSK2; TSK-2; TSSK- ...... |
Chromosomal Location | 22q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TSSK2 collected from DrugBank database. |
There is no record. |