Summary | |
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Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane Cytoplasm, cytoskeleton Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions. |
Domain |
PF13181 Tetratricopeptide repeat |
Function |
Plays a role in primary ciliogenesis by modulating actin polymerization. |
Biological Process |
GO:0007015 actin filament organization GO:0008154 actin polymerization or depolymerization GO:0030041 actin filament polymerization GO:0044782 cilium organization GO:0051258 protein polymerization |
Molecular Function | - |
Cellular Component |
GO:0015629 actin cytoskeleton |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TTC17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TTC17 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TTC17 in various data sets.
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Points in the above scatter plot represent the mutation difference of TTC17 in various data sets.
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Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TTC17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TTC17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TTC17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TTC17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TTC17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TTC17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TTC17 |
Name | tetratricopeptide repeat domain 17 |
Aliases | FLJ10890; TPR repeat protein 17; Tetratricopeptide repeat protein 17 |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TTC17 collected from DrugBank database. |
There is no record. |