Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme |
Domain |
PF03133 Tubulin-tyrosine ligase family |
Function |
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0010927 cellular component assembly involved in morphogenesis GO:0018094 protein polyglycylation GO:0030031 cell projection assembly GO:0035082 axoneme assembly GO:0042384 cilium assembly GO:0044782 cilium organization GO:0060271 cilium morphogenesis |
Molecular Function |
GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0016881 acid-amino acid ligase activity GO:0070735 protein-glycine ligase activity GO:0070736 protein-glycine ligase activity, initiating |
Cellular Component |
GO:0005874 microtubule GO:0005929 cilium GO:0005930 axoneme GO:0044441 ciliary part GO:0097014 ciliary plasm |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TTLL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TTLL3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TTLL3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TTLL3 in various data sets.
|
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TTLL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TTLL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TTLL3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TTLL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TTLL3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TTLL3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TTLL3 |
Name | tubulin tyrosine ligase-like family member 3 |
Aliases | DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ...... |
Chromosomal Location | 3p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TTLL3 collected from DrugBank database. |
Details on drugs targeting TTLL3.
|