Browse TTLL3

Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme
Domain PF03133 Tubulin-tyrosine ligase family
Function

Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0010927 cellular component assembly involved in morphogenesis
GO:0018094 protein polyglycylation
GO:0030031 cell projection assembly
GO:0035082 axoneme assembly
GO:0042384 cilium assembly
GO:0044782 cilium organization
GO:0060271 cilium morphogenesis
Molecular Function GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0016881 acid-amino acid ligase activity
GO:0070735 protein-glycine ligase activity
GO:0070736 protein-glycine ligase activity, initiating
Cellular Component GO:0005874 microtubule
GO:0005929 cilium
GO:0005930 axoneme
GO:0044441 ciliary part
GO:0097014 ciliary plasm
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TTLL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TTLL3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TTLL3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4010.156
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.890.255
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0480.943
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2250.558
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0430.988
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5650.88
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1660.656
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3360.754
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6620.549
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4380.767
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1420.563
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1030.298
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TTLL3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TTLL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TTLL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TTLL3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TTLL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TTLL3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TTLL3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTTLL3
Nametubulin tyrosine ligase-like family member 3
Aliases DKFZP434B103; HOTTL; tubulin tyrosine ligase-like family, member 3; tubulin--tyrosine ligase-like protein 3; ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TTLL3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TTLL3.
ID Name Drug Type Targets #Targets
DB00277TheophyllineSmall MoleculeADORA1, ADORA2A, ADORA2B, CPNE1, HDAC2, HM13, NOMO1, PARP1, PDE3A, ......14