Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Nucleus Cytoplasm Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. |
Domain |
PF03133 Tubulin-tyrosine ligase family |
Function |
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317). |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0001654 eye development GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007288 sperm axoneme assembly GO:0007423 sensory organ development GO:0009566 fertilization GO:0010927 cellular component assembly involved in morphogenesis GO:0018095 protein polyglutamylation GO:0018200 peptidyl-glutamic acid modification GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030031 cell projection assembly GO:0030317 flagellated sperm motility GO:0035082 axoneme assembly GO:0042384 cilium assembly GO:0043010 camera-type eye development GO:0044782 cilium organization GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0060041 retina development in camera-type eye GO:0060271 cilium morphogenesis GO:0097722 sperm motility |
Molecular Function |
GO:0016874 ligase activity |
Cellular Component |
GO:0005813 centrosome GO:0005874 microtubule GO:0005929 cilium |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TTLL5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TTLL5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TTLL5 in various data sets.
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Points in the above scatter plot represent the mutation difference of TTLL5 in various data sets.
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Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TTLL5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TTLL5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TTLL5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TTLL5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TTLL5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TTLL5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TTLL5 |
Name | tubulin tyrosine ligase-like family member 5 |
Aliases | KIAA0998; CORD19; STAMP; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory prote ...... |
Chromosomal Location | 14q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TTLL5 collected from DrugBank database. |
There is no record. |