Browse TUBB2B

Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton
Domain PF00091 Tubulin/FtsZ family
PF03953 Tubulin C-terminal domain
Function

Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).

> Gene Ontology
 
Biological Process GO:0001764 neuron migration
Molecular Function GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0005874 microtubule
> KEGG and Reactome Pathway
 
KEGG hsa04145 Phagosome
hsa04540 Gap junction
Reactome R-HSA-390466: Chaperonin-mediated protein folding
R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-389960: Formation of tubulin folding intermediates by CCT/TriC
R-HSA-392499: Metabolism of proteins
R-HSA-389977: Post-chaperonin tubulin folding pathway
R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-391251: Protein folding
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TUBB2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TUBB2B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.04; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TUBB2B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0140.983
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4590.849
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3120.863
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.9390.102
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.4570.333
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2970.891
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1220.791
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0230.989
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.170.924
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0780.953
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8450.64
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4790.0745
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TUBB2B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TUBB2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TUBB2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TUBB2B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TUBB2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TUBB2B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TUBB2B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTUBB2B
Nametubulin, beta 2B class IIb
Aliases MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ......
Chromosomal Location6p25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TUBB2B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TUBB2B.
ID Name Drug Type Targets #Targets
DB05147CYT997Small MoleculeTUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2 ......14
DB075742-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDESmall MoleculeSTMN4, TUBA1A, TUBA1B, TUBA1C, TUBB2B5