Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton |
Domain |
PF00091 Tubulin/FtsZ family PF03953 Tubulin C-terminal domain |
Function |
Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). |
Biological Process |
GO:0001764 neuron migration |
Molecular Function |
GO:0003924 GTPase activity GO:0005200 structural constituent of cytoskeleton GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0005874 microtubule |
KEGG |
hsa04145 Phagosome hsa04540 Gap junction |
Reactome |
R-HSA-390466: Chaperonin-mediated protein folding R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389960: Formation of tubulin folding intermediates by CCT/TriC R-HSA-392499: Metabolism of proteins R-HSA-389977: Post-chaperonin tubulin folding pathway R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-391251: Protein folding |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TUBB2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TUBB2B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TUBB2B in various data sets.
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Points in the above scatter plot represent the mutation difference of TUBB2B in various data sets.
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Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TUBB2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TUBB2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TUBB2B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TUBB2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TUBB2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TUBB2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TUBB2B |
Name | tubulin, beta 2B class IIb |
Aliases | MGC8685; DKFZp566F223; bA506K6.1; class IIb beta-tubulin; tubulin, beta 2B; PMGYSA; class II beta-tubulin is ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TUBB2B collected from DrugBank database. |
Details on drugs targeting TUBB2B.
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