Summary | |
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Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF15000 Tumour suppressor candidate 2 |
Function |
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. |
Biological Process |
GO:0001779 natural killer cell differentiation GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002521 leukocyte differentiation GO:0006909 phagocytosis GO:0021700 developmental maturation GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0031640 killing of cells of other organism GO:0032602 chemokine production GO:0032613 interleukin-10 production GO:0032618 interleukin-15 production GO:0032620 interleukin-17 production GO:0032653 regulation of interleukin-10 production GO:0032660 regulation of interleukin-17 production GO:0032700 negative regulation of interleukin-17 production GO:0032733 positive regulation of interleukin-10 production GO:0035821 modification of morphology or physiology of other organism GO:0042391 regulation of membrane potential GO:0042742 defense response to bacterium GO:0044364 disruption of cells of other organism GO:0048469 cell maturation GO:0050829 defense response to Gram-negative bacterium GO:0051701 interaction with host GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051818 disruption of cells of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0051852 disruption by host of symbiont cells GO:0051873 killing by host of symbiont cells GO:0051881 regulation of mitochondrial membrane potential GO:0051883 killing of cells in other organism involved in symbiotic interaction GO:0052173 response to defenses of other organism involved in symbiotic interaction GO:0052200 response to host defenses GO:0052550 response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction GO:0052564 response to immune response of other organism involved in symbiotic interaction GO:0052567 response to defense-related host reactive oxygen species production GO:0052572 response to host immune response GO:0070942 neutrophil mediated cytotoxicity GO:0070943 neutrophil mediated killing of symbiont cell GO:0070944 neutrophil mediated killing of bacterium GO:0070945 neutrophil mediated killing of gram-negative bacterium GO:0071609 chemokine (C-C motif) ligand 5 production GO:0072593 reactive oxygen species metabolic process GO:0075136 response to host GO:0098542 defense response to other organism GO:2000377 regulation of reactive oxygen species metabolic process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TUSC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TUSC2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TUSC2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TUSC2 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TUSC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TUSC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TUSC2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TUSC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TUSC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TUSC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TUSC2 |
Name | tumor suppressor candidate 2 |
Aliases | C3orf11; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; fus-1 protein; fusion 1 protein |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TUSC2 collected from DrugBank database. |
There is no record. |