Browse TWIST1

Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00010 Helix-loop-helix DNA-binding domain
Function

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001701 in utero embryonic development
GO:0001755 neural crest cell migration
GO:0001764 neuron migration
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003170 heart valve development
GO:0003171 atrioventricular valve development
GO:0003174 mitral valve development
GO:0003176 aortic valve development
GO:0003179 heart valve morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003188 heart valve formation
GO:0003197 endocardial cushion development
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003203 endocardial cushion morphogenesis
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006352 DNA-templated transcription, initiation
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006818 hydrogen transport
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007568 aging
GO:0007569 cell aging
GO:0009062 fatty acid catabolic process
GO:0009306 protein secretion
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010155 regulation of proton transport
GO:0010565 regulation of cellular ketone metabolic process
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014020 primary neural tube formation
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0015672 monovalent inorganic cation transport
GO:0015992 proton transport
GO:0016042 lipid catabolic process
GO:0016054 organic acid catabolic process
GO:0016202 regulation of striated muscle tissue development
GO:0016331 morphogenesis of embryonic epithelium
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019395 fatty acid oxidation
GO:0021915 neural tube development
GO:0022898 regulation of transmembrane transporter activity
GO:0030258 lipid modification
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030282 bone mineralization
GO:0030326 embryonic limb morphogenesis
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030500 regulation of bone mineralization
GO:0030522 intracellular receptor signaling pathway
GO:0031056 regulation of histone modification
GO:0031057 negative regulation of histone modification
GO:0031076 embryonic camera-type eye development
GO:0031214 biomineral tissue development
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031334 positive regulation of protein complex assembly
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032602 chemokine production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032642 regulation of chemokine production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033127 regulation of histone phosphorylation
GO:0033128 negative regulation of histone phosphorylation
GO:0034440 lipid oxidation
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0035051 cardiocyte differentiation
GO:0035065 regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0040017 positive regulation of locomotion
GO:0042180 cellular ketone metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042471 ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0042770 signal transduction in response to DNA damage
GO:0043010 camera-type eye development
GO:0043254 regulation of protein complex assembly
GO:0043271 negative regulation of ion transport
GO:0043388 positive regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043543 protein acylation
GO:0043583 ear development
GO:0044089 positive regulation of cellular component biogenesis
GO:0044242 cellular lipid catabolic process
GO:0044282 small molecule catabolic process
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045738 negative regulation of DNA repair
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045834 positive regulation of lipid metabolic process
GO:0045843 negative regulation of striated muscle tissue development
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046320 regulation of fatty acid oxidation
GO:0046321 positive regulation of fatty acid oxidation
GO:0046395 carboxylic acid catabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048048 embryonic eye morphogenesis
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048634 regulation of muscle organ development
GO:0048635 negative regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048736 appendage development
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050663 cytokine secretion
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050994 regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0051047 positive regulation of secretion
GO:0051051 negative regulation of transport
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051101 regulation of DNA binding
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0060021 palate development
GO:0060173 limb development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060363 cranial suture morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060900 embryonic camera-type eye formation
GO:0060973 cell migration involved in heart development
GO:0061029 eyelid development in camera-type eye
GO:0061307 cardiac neural crest cell differentiation involved in heart development
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0070167 regulation of biomineral tissue development
GO:0070482 response to oxygen levels
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071605 monocyte chemotactic protein-1 production
GO:0071637 regulation of monocyte chemotactic protein-1 production
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0072132 mesenchyme morphogenesis
GO:0072175 epithelial tube formation
GO:0072329 monocarboxylic acid catabolic process
GO:0072331 signal transduction by p53 class mediator
GO:0072604 interleukin-6 secretion
GO:0090342 regulation of cell aging
GO:0090344 negative regulation of cell aging
GO:0090398 cellular senescence
GO:0090500 endocardial cushion to mesenchymal transition
GO:0090596 sensory organ morphogenesis
GO:0097094 craniofacial suture morphogenesis
GO:1901342 regulation of vasculature development
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901983 regulation of protein acetylation
GO:1901984 negative regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1902532 negative regulation of intracellular signal transduction
GO:1903532 positive regulation of secretion by cell
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1904018 positive regulation of vasculature development
GO:1904888 cranial skeletal system development
GO:1904951 positive regulation of establishment of protein localization
GO:1905268 negative regulation of chromatin organization
GO:1905314 semi-lunar valve development
GO:2000027 regulation of organ morphogenesis
GO:2000142 regulation of DNA-templated transcription, initiation
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2000147 positive regulation of cell motility
GO:2000275 regulation of oxidative phosphorylation uncoupler activity
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000772 regulation of cellular senescence
GO:2000773 negative regulation of cellular senescence
GO:2000778 positive regulation of interleukin-6 secretion
GO:2000779 regulation of double-strand break repair
GO:2000780 negative regulation of double-strand break repair
GO:2000793 cell proliferation involved in heart valve development
GO:2000800 regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
GO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
GO:2000826 regulation of heart morphogenesis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001021 negative regulation of response to DNA damage stimulus
Molecular Function GO:0008134 transcription factor binding
GO:0043425 bHLH transcription factor binding
GO:0046982 protein heterodimerization activity
GO:0070888 E-box binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TWIST1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TWIST1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24048332Castration-Resistant Prostate CarcinomaImmunotherapy targetMale C57BL/6 or TRAMP (transgenic adenocarcinoma of the mouse prostate) prostate cancer model mice were exposed to enzalutamide and/or a therapeutic vaccine targeting Twist, an antigen involved in epithelial-to-mesenchymal transition and metastasis. Twist was confirmed as a valid tumor antigen in TRAMP mice by immunohistochemistry. The combination of enzalutamide and Twist-vaccine resulted in significantly increased overall survival of TRAMP mice compared with other treatment groups (27.5 vs. 10.3 weeks).
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TWIST1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TWIST1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4750.337
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7270.708
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2930.843
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4360.521
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.050.973
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.9230.607
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2490.656
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4670.648
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.0910.304
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5190.469
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6560.486
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1670.502
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TWIST1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TWIST1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TWIST1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TWIST1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TWIST1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TWIST1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TWIST1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Aliases SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ......
Chromosomal Location7p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TWIST1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.