Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain |
Function |
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001525 angiogenesis GO:0001649 osteoblast differentiation GO:0001654 eye development GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001755 neural crest cell migration GO:0001764 neuron migration GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001837 epithelial to mesenchymal transition GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001933 negative regulation of protein phosphorylation GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003174 mitral valve development GO:0003176 aortic valve development GO:0003179 heart valve morphogenesis GO:0003180 aortic valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003183 mitral valve morphogenesis GO:0003188 heart valve formation GO:0003197 endocardial cushion development GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003203 endocardial cushion morphogenesis GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0006282 regulation of DNA repair GO:0006302 double-strand break repair GO:0006352 DNA-templated transcription, initiation GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006818 hydrogen transport GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007568 aging GO:0007569 cell aging GO:0009062 fatty acid catabolic process GO:0009306 protein secretion GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010155 regulation of proton transport GO:0010565 regulation of cellular ketone metabolic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0014020 primary neural tube formation GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling GO:0014706 striated muscle tissue development GO:0015672 monovalent inorganic cation transport GO:0015992 proton transport GO:0016042 lipid catabolic process GO:0016054 organic acid catabolic process GO:0016202 regulation of striated muscle tissue development GO:0016331 morphogenesis of embryonic epithelium GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0021915 neural tube development GO:0022898 regulation of transmembrane transporter activity GO:0030258 lipid modification GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030282 bone mineralization GO:0030326 embryonic limb morphogenesis GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030500 regulation of bone mineralization GO:0030522 intracellular receptor signaling pathway GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031076 embryonic camera-type eye development GO:0031214 biomineral tissue development GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031334 positive regulation of protein complex assembly GO:0031998 regulation of fatty acid beta-oxidation GO:0032000 positive regulation of fatty acid beta-oxidation GO:0032409 regulation of transporter activity GO:0032410 negative regulation of transporter activity GO:0032602 chemokine production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032720 negative regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0033127 regulation of histone phosphorylation GO:0033128 negative regulation of histone phosphorylation GO:0034440 lipid oxidation GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0035051 cardiocyte differentiation GO:0035065 regulation of histone acetylation GO:0035067 negative regulation of histone acetylation GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035357 peroxisome proliferator activated receptor signaling pathway GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040017 positive regulation of locomotion GO:0042180 cellular ketone metabolic process GO:0042326 negative regulation of phosphorylation GO:0042471 ear morphogenesis GO:0042473 outer ear morphogenesis GO:0042476 odontogenesis GO:0042733 embryonic digit morphogenesis GO:0042770 signal transduction in response to DNA damage GO:0043010 camera-type eye development GO:0043254 regulation of protein complex assembly GO:0043271 negative regulation of ion transport GO:0043388 positive regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043543 protein acylation GO:0043583 ear development GO:0044089 positive regulation of cellular component biogenesis GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045738 negative regulation of DNA repair GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045834 positive regulation of lipid metabolic process GO:0045843 negative regulation of striated muscle tissue development GO:0045923 positive regulation of fatty acid metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046321 positive regulation of fatty acid oxidation GO:0046395 carboxylic acid catabolic process GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048048 embryonic eye morphogenesis GO:0048511 rhythmic process GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048642 negative regulation of skeletal muscle tissue development GO:0048701 embryonic cranial skeleton morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050994 regulation of lipid catabolic process GO:0050996 positive regulation of lipid catabolic process GO:0051047 positive regulation of secretion GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0060021 palate development GO:0060173 limb development GO:0060317 cardiac epithelial to mesenchymal transition GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060363 cranial suture morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060900 embryonic camera-type eye formation GO:0060973 cell migration involved in heart development GO:0061029 eyelid development in camera-type eye GO:0061307 cardiac neural crest cell differentiation involved in heart development GO:0061308 cardiac neural crest cell development involved in heart development GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis GO:0070167 regulation of biomineral tissue development GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071605 monocyte chemotactic protein-1 production GO:0071637 regulation of monocyte chemotactic protein-1 production GO:0071639 positive regulation of monocyte chemotactic protein-1 production GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072132 mesenchyme morphogenesis GO:0072175 epithelial tube formation GO:0072329 monocarboxylic acid catabolic process GO:0072331 signal transduction by p53 class mediator GO:0072604 interleukin-6 secretion GO:0090342 regulation of cell aging GO:0090344 negative regulation of cell aging GO:0090398 cellular senescence GO:0090500 endocardial cushion to mesenchymal transition GO:0090596 sensory organ morphogenesis GO:0097094 craniofacial suture morphogenesis GO:1901342 regulation of vasculature development GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1901983 regulation of protein acetylation GO:1901984 negative regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904018 positive regulation of vasculature development GO:1904888 cranial skeletal system development GO:1904951 positive regulation of establishment of protein localization GO:1905268 negative regulation of chromatin organization GO:1905314 semi-lunar valve development GO:2000027 regulation of organ morphogenesis GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation GO:2000147 positive regulation of cell motility GO:2000275 regulation of oxidative phosphorylation uncoupler activity GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity GO:2000677 regulation of transcription regulatory region DNA binding GO:2000679 positive regulation of transcription regulatory region DNA binding GO:2000756 regulation of peptidyl-lysine acetylation GO:2000757 negative regulation of peptidyl-lysine acetylation GO:2000772 regulation of cellular senescence GO:2000773 negative regulation of cellular senescence GO:2000778 positive regulation of interleukin-6 secretion GO:2000779 regulation of double-strand break repair GO:2000780 negative regulation of double-strand break repair GO:2000793 cell proliferation involved in heart valve development GO:2000800 regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000826 regulation of heart morphogenesis GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus |
Molecular Function |
GO:0008134 transcription factor binding GO:0043425 bHLH transcription factor binding GO:0046982 protein heterodimerization activity GO:0070888 E-box binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TWIST1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TWIST1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TWIST1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TWIST1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TWIST1 in various data sets.
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Summary | |
---|---|
Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TWIST1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TWIST1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TWIST1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TWIST1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TWIST1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TWIST1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TWIST1 |
Name | twist family bHLH transcription factor 1 |
Aliases | SCS; H-twist; BPES2; bHLHa38; CRS1; Saethre-Chotzen syndrome; BPES3; TWIST; CRS; blepharophimosis, epicanthu ...... |
Chromosomal Location | 7p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TWIST1 collected from DrugBank database. |
There is no record. |