Summary | |
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Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain |
Function |
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TWIST2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TWIST2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TWIST2 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TWIST2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TWIST2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TWIST2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TWIST2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TWIST2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TWIST2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TWIST2 |
Name | twist family bHLH transcription factor 2 |
Aliases | DERMO1; Dermo-1; bHLHa39; twist homolog 2 (Drosophila); twist basic helix-loop-helix transcription factor 2; ...... |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TWIST2 collected from DrugBank database. |
There is no record. |