Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Melanosome membrane Single-pass type I membrane protein Melanosome Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. |
Domain |
PF00264 Common central domain of tyrosinase |
Function |
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
Biological Process |
GO:0006570 tyrosine metabolic process GO:0006582 melanin metabolic process GO:0006583 melanin biosynthetic process from tyrosine GO:0006726 eye pigment biosynthetic process GO:0007584 response to nutrient GO:0007601 visual perception GO:0009072 aromatic amino acid family metabolic process GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009991 response to extracellular stimulus GO:0014074 response to purine-containing compound GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0031667 response to nutrient levels GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0042441 eye pigment metabolic process GO:0043324 pigment metabolic process involved in developmental pigmentation GO:0043473 pigmentation GO:0043474 pigment metabolic process involved in pigmentation GO:0044550 secondary metabolite biosynthetic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0046683 response to organophosphorus GO:0048066 developmental pigmentation GO:0048069 eye pigmentation GO:0048538 thymus development GO:0048732 gland development GO:0050953 sensory perception of light stimulus GO:0051591 response to cAMP GO:1901605 alpha-amino acid metabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function |
GO:0004497 monooxygenase activity GO:0004503 monophenol monooxygenase activity GO:0005507 copper ion binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0005798 Golgi-associated vesicle GO:0030659 cytoplasmic vesicle membrane GO:0033162 melanosome membrane GO:0042470 melanosome GO:0045009 chitosome GO:0048770 pigment granule |
KEGG |
hsa04916 Melanogenesis hsa00350 Tyrosine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5662702: Melanin biosynthesis R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TYR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TYR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TYR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TYR in various data sets.
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Points in the above scatter plot represent the mutation difference of TYR in various data sets.
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Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TYR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TYR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TYR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TYR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TYR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TYR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TYR |
Name | tyrosinase |
Aliases | OCAIA; OCA1A; OCA1; oculocutaneous albinism IA; ATN; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; tumo ...... |
Chromosomal Location | 11q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TYR collected from DrugBank database. |
Details on drugs targeting TYR.
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