Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Melanosome membrane Single-pass type I membrane protein Melanosome Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. |
Domain |
PF00264 Common central domain of tyrosinase |
Function |
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). |
Biological Process |
GO:0006582 melanin metabolic process GO:0006631 fatty acid metabolic process GO:0016050 vesicle organization GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0030318 melanocyte differentiation GO:0032438 melanosome organization GO:0033059 cellular pigmentation GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0043438 acetoacetic acid metabolic process GO:0043455 regulation of secondary metabolic process GO:0043473 pigmentation GO:0044550 secondary metabolite biosynthetic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0046459 short-chain fatty acid metabolic process GO:0048021 regulation of melanin biosynthetic process GO:0048023 positive regulation of melanin biosynthetic process GO:0048066 developmental pigmentation GO:0048753 pigment granule organization GO:0050931 pigment cell differentiation GO:1900376 regulation of secondary metabolite biosynthetic process GO:1900378 positive regulation of secondary metabolite biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function |
GO:0004497 monooxygenase activity GO:0005507 copper ion binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0010008 endosome membrane GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0033162 melanosome membrane GO:0042470 melanosome GO:0044440 endosomal part GO:0045009 chitosome GO:0045334 clathrin-coated endocytic vesicle GO:0048770 pigment granule |
KEGG |
hsa04916 Melanogenesis hsa00350 Tyrosine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5662702: Melanin biosynthesis R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TYRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TYRP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TYRP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TYRP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TYRP1 in various data sets.
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Summary | |
---|---|
Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TYRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TYRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TYRP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TYRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TYRP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TYRP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TYRP1 |
Name | tyrosinase-related protein 1 |
Aliases | GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ...... |
Chromosomal Location | 9p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TYRP1 collected from DrugBank database. |
There is no record. |