Browse TYRP1

Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Melanosome membrane Single-pass type I membrane protein Melanosome Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Domain PF00264 Common central domain of tyrosinase
Function

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).

> Gene Ontology
 
Biological Process GO:0006582 melanin metabolic process
GO:0006631 fatty acid metabolic process
GO:0016050 vesicle organization
GO:0018958 phenol-containing compound metabolic process
GO:0019748 secondary metabolic process
GO:0030318 melanocyte differentiation
GO:0032438 melanosome organization
GO:0033059 cellular pigmentation
GO:0042438 melanin biosynthetic process
GO:0042440 pigment metabolic process
GO:0043438 acetoacetic acid metabolic process
GO:0043455 regulation of secondary metabolic process
GO:0043473 pigmentation
GO:0044550 secondary metabolite biosynthetic process
GO:0046148 pigment biosynthetic process
GO:0046189 phenol-containing compound biosynthetic process
GO:0046459 short-chain fatty acid metabolic process
GO:0048021 regulation of melanin biosynthetic process
GO:0048023 positive regulation of melanin biosynthetic process
GO:0048066 developmental pigmentation
GO:0048753 pigment granule organization
GO:0050931 pigment cell differentiation
GO:1900376 regulation of secondary metabolite biosynthetic process
GO:1900378 positive regulation of secondary metabolite biosynthetic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
Molecular Function GO:0004497 monooxygenase activity
GO:0005507 copper ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0046982 protein heterodimerization activity
Cellular Component GO:0010008 endosome membrane
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
GO:0044440 endosomal part
GO:0045009 chitosome
GO:0045334 clathrin-coated endocytic vesicle
GO:0048770 pigment granule
> KEGG and Reactome Pathway
 
KEGG hsa04916 Melanogenesis
hsa00350 Tyrosine metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-5662702: Melanin biosynthesis
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TYRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TYRP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23633494B16 Malignant MelanomaPromote immunity (infiltration); Promote immunity (T cell function); essential for immunotherapySimultaneous transfer of genetically engineered syngeneic T cells expressing a chimeric antigen receptor targeting the VEGF receptor-2 (VEGFR2; KDR) that is overexpressed on tumor vasculature and T-cells specific for the tumor antigens gp100 (PMEL), TRP-1 (TYRP1), or TRP-2 (DCT) synergistically eradicated established B16 melanoma tumors in mice and dramatically increased the tumor-free survival of mice compared with treatment with either cell type alone or T cells coexpressing these two targeting molecules. The synergistic antitumor response was accompanied by a significant increase in the infiltration and expansion and/or persistence of the adoptively transferred tumor antigen-specific T cells in the tumor microenvironment and thus enhanced their antitumor potency.
29602773melanomaPromote immunity (T cell function); increase the efficacy of immunotherapyPreviously, we showed that tumor-specific, cytotoxic CD4+ T cells from tyrosinase-related protein 1 transgenic mice could overcome secondary resistance to recurring melanoma when anti-programmed cell death 1 ligand (PD-L1) checkpoint blockade was combined with either anti-lymphocyte-activated gene 3 (LAG-3) Abs or depletion of tumor-specific regulatory T (Treg) cells.
23370329MelanomaPromote immunityIn this study, we show that Aire deficiency decreases thymic expression of TRP-1 (TYRP1), which is a self-antigen in melanocytes and a cancer antigen in melanomas. Aire deficiency resulted in defective negative selection of TRP-1-specific T cells without affecting thymic numbers of regulatory T cells.
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TYRP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TYRP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5040.749
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3340.905
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6830.809
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5110.541
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9580.444
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.060.968
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4090.77
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1660.947
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.1980.674
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5670.469
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5670.592
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0680.83
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TYRP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TYRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TYRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TYRP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TYRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TYRP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TYRP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTYRP1
Nametyrosinase-related protein 1
Aliases GP75; CATB; TRP; b-PROTEIN; OCA3; TYRP; DHICA oxidase; catalase B; glycoprotein 75; melanoma antigen gp75; 5 ......
Chromosomal Location9p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TYRP1 collected from DrugBank database.
> Drugs from DrugBank database
 

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