Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16191 Ubiquitin-activating enzyme E1 four-helix bundle PF16190 Ubiquitin-activating enzyme E1 FCCH domain PF09358 Ubiquitin fold domain PF00899 ThiF family PF10585 Ubiquitin-activating enzyme active site |
Function |
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
Biological Process |
GO:0007611 learning or memory GO:0007612 learning GO:0007626 locomotory behavior GO:0016358 dendrite development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021764 amygdala development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0044708 single-organism behavior GO:0050890 cognition GO:0060996 dendritic spine development |
Molecular Function |
GO:0004839 ubiquitin activating enzyme activity GO:0008641 small protein activating enzyme activity GO:0016874 ligase activity GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0019780 FAT10 activating enzyme activity |
Cellular Component | - |
KEGG |
hsa04120 Ubiquitin mediated proteolysis |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination R-HSA-8866652: Synthesis of active ubiquitin |
Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UBA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UBA6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UBA6 in various data sets.
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Points in the above scatter plot represent the mutation difference of UBA6 in various data sets.
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Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBA6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UBA6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UBA6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UBA6 |
Name | ubiquitin-like modifier activating enzyme 6 |
Aliases | FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ...... |
Chromosomal Location | 4q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UBA6 collected from DrugBank database. |
There is no record. |