Browse UBE2A

Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00179 Ubiquitin-conjugating enzyme
Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

> Gene Ontology
 
Biological Process GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0006301 postreplication repair
GO:0007565 female pregnancy
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0010498 proteasomal protein catabolic process
GO:0016570 histone modification
GO:0016574 histone ubiquitination
GO:0033522 histone H2A ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044706 multi-multicellular organism process
GO:0051865 protein autoubiquitination
GO:0060135 maternal process involved in female pregnancy
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Molecular Function GO:0004842 ubiquitin-protein transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032182 ubiquitin-like protein binding
GO:0043130 ubiquitin binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0061631 ubiquitin conjugating enzyme activity
GO:0061650 ubiquitin-like protein conjugating enzyme activity
GO:0061659 ubiquitin-like protein ligase activity
Cellular Component GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0000803 sex chromosome
GO:0001741 XY body
GO:0031371 ubiquitin conjugating enzyme complex
GO:0033503 HULC complex
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG hsa04120 Ubiquitin mediated proteolysis
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983168: Antigen processing
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-168256: Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8852135: Protein ubiquitination
R-HSA-8866652: Synthesis of active ubiquitin
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UBE2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UBE2A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -1.97; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UBE2A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2280.277
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4830.85
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0460.98
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0670.823
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0740.962
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2390.909
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.270.507
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1460.936
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3810.846
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1890.911
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5520.834
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1320.0316
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBE2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBE2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBE2A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBE2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UBE2A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UBE2A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUBE2A
Nameubiquitin-conjugating enzyme E2A
Aliases HHR6A; RAD6A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); MRXS30; MRXSN; RAD6 homolog A; ubiquitin carr ......
Chromosomal LocationXq24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UBE2A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.