Summary | |
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Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00179 Ubiquitin-conjugating enzyme |
Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). |
Biological Process |
GO:0000209 protein polyubiquitination GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0018196 peptidyl-asparagine modification GO:0018279 protein N-linked glycosylation via asparagine GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032527 protein exit from endoplasmic reticulum GO:0033157 regulation of intracellular protein transport GO:0034976 response to endoplasmic reticulum stress GO:0035456 response to interferon-beta GO:0035458 cellular response to interferon-beta GO:0036503 ERAD pathway GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043413 macromolecule glycosylation GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0070085 glycosylation GO:0070861 regulation of protein exit from endoplasmic reticulum GO:0070862 negative regulation of protein exit from endoplasmic reticulum GO:0070936 protein K48-linked ubiquitination GO:0090317 negative regulation of intracellular protein transport GO:1903513 endoplasmic reticulum to cytosol transport GO:1903573 negative regulation of response to endoplasmic reticulum stress GO:1903828 negative regulation of cellular protein localization GO:1904152 regulation of retrograde protein transport, ER to cytosol GO:1904153 negative regulation of retrograde protein transport, ER to cytosol GO:1904292 regulation of ERAD pathway GO:1904293 negative regulation of ERAD pathway GO:1904950 negative regulation of establishment of protein localization |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061631 ubiquitin conjugating enzyme activity GO:0061650 ubiquitin-like protein conjugating enzyme activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component | - |
KEGG |
hsa04120 Ubiquitin mediated proteolysis hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination R-HSA-8866652: Synthesis of active ubiquitin |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UBE2G2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UBE2G2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UBE2G2 in various data sets.
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Points in the above scatter plot represent the mutation difference of UBE2G2 in various data sets.
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Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBE2G2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBE2G2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBE2G2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBE2G2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UBE2G2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UBE2G2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UBE2G2 |
Name | ubiquitin-conjugating enzyme E2G 2 |
Aliases | ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7); ubiquitin-conjugating enzyme E2G 2 (UBC7 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UBE2G2 collected from DrugBank database. |
There is no record. |