Summary | |
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Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00179 Ubiquitin-conjugating enzyme |
Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. |
Biological Process |
GO:0000209 protein polyubiquitination GO:0010498 proteasomal protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070936 protein K48-linked ubiquitination GO:0070979 protein K11-linked ubiquitination |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061631 ubiquitin conjugating enzyme activity GO:0061650 ubiquitin-like protein conjugating enzyme activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component | - |
KEGG |
hsa04120 Ubiquitin mediated proteolysis |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination R-HSA-8866652: Synthesis of active ubiquitin |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UBE2H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UBE2H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UBE2H in various data sets.
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Points in the above scatter plot represent the mutation difference of UBE2H in various data sets.
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Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBE2H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBE2H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBE2H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBE2H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UBE2H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UBE2H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UBE2H |
Name | ubiquitin-conjugating enzyme E2H |
Aliases | UBCH; UBC8; GID3; GID complex subunit 3, UBC8 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2H (hom ...... |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UBE2H collected from DrugBank database. |
There is no record. |