Browse UBR4

Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Domain PF13764 E3 ubiquitin-protein ligase UBR4
PF02207 Putative zinc finger in N-recognin (UBR box)
Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

> Gene Ontology
 
Biological Process GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Molecular Function GO:0004842 ubiquitin-protein transferase activity
GO:0005516 calmodulin binding
GO:0016874 ligase activity
GO:0019787 ubiquitin-like protein transferase activity
Cellular Component GO:0005813 centrosome
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983168: Antigen processing
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UBR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UBR4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.35; FDR: 0.01650 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UBR4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1910.303
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1670.921
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4510.709
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3030.434
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0990.977
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8140.854
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3470.421
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3620.854
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3290.882
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7040.756
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2590.94
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0270.454
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of UBR4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.89.65.20.482
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.811.92.90.735
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21171911.87.20.672
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.818.212.60.649
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.36.227.10.116
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111318.2018.20.199
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6133.3033.31
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBR4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UBR4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UBR4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUBR4
Nameubiquitin protein ligase E3 component n-recognin 4
Aliases KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UBR4 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting UBR4.
ID Name Drug Type Targets #Targets
DB04959HspE7BiotechKRT7, UBR42
DB05483PCL-016Small MoleculeUBR4, ZFY2