Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility. |
Domain |
PF13764 E3 ubiquitin-protein ligase UBR4 PF02207 Putative zinc finger in N-recognin (UBR box) |
Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. |
Biological Process |
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0005516 calmodulin binding GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity |
Cellular Component |
GO:0005813 centrosome |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UBR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UBR4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UBR4 in various data sets.
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Points in the above scatter plot represent the mutation difference of UBR4 in various data sets.
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Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBR4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UBR4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UBR4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | UBR4 |
Name | ubiquitin protein ligase E3 component n-recognin 4 |
Aliases | KIAA1307; KIAA0462; RBAF600; ZUBR1; zinc finger, UBR1 type 1; N-recognin-4; retinoblastoma-associated factor ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UBR4 collected from DrugBank database. |
Details on drugs targeting UBR4.
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