Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF11547 E3 ubiquitin ligase EDD PF00632 HECT-domain (ubiquitin-transferase) PF00658 Poly-adenylate binding protein |
Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. |
Biological Process |
GO:0000060 protein import into nucleus, translocation GO:0000209 protein polyubiquitination GO:0006282 regulation of DNA repair GO:0006302 double-strand break repair GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0009755 hormone-mediated signaling pathway GO:0016055 Wnt signaling pathway GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0017038 protein import GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0033158 regulation of protein import into nucleus, translocation GO:0033160 positive regulation of protein import into nucleus, translocation GO:0033182 regulation of histone ubiquitination GO:0033183 negative regulation of histone ubiquitination GO:0033522 histone H2A ubiquitination GO:0034504 protein localization to nucleus GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035413 positive regulation of catenin import into nucleus GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043401 steroid hormone mediated signaling pathway GO:0044744 protein targeting to nucleus GO:0045738 negative regulation of DNA repair GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048545 response to steroid hormone GO:0050847 progesterone receptor signaling pathway GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0070534 protein K63-linked ubiquitination GO:0070535 histone H2A K63-linked ubiquitination GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090316 positive regulation of intracellular protein transport GO:0198738 cell-cell signaling by wnt GO:1900044 regulation of protein K63-linked ubiquitination GO:1900045 negative regulation of protein K63-linked ubiquitination GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901314 regulation of histone H2A K63-linked ubiquitination GO:1901315 negative regulation of histone H2A K63-linked ubiquitination GO:1902275 regulation of chromatin organization GO:1902593 single-organism nuclear import GO:1902914 regulation of protein polyubiquitination GO:1902915 negative regulation of protein polyubiquitination GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:1905268 negative regulation of chromatin organization GO:2000779 regulation of double-strand break repair GO:2000780 negative regulation of double-strand break repair GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity GO:0032182 ubiquitin-like protein binding GO:0034450 ubiquitin-ubiquitin ligase activity GO:0043130 ubiquitin binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component | - |
KEGG |
hsa04120 Ubiquitin mediated proteolysis |
Reactome | - |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UBR5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UBR5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UBR5 in various data sets.
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Points in the above scatter plot represent the mutation difference of UBR5 in various data sets.
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Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBR5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBR5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBR5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBR5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UBR5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UBR5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | UBR5 |
Name | ubiquitin protein ligase E3 component n-recognin 5 |
Aliases | DD5; HYD; EDD; KIAA0896; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 identified by diff ...... |
Chromosomal Location | 8q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UBR5 collected from DrugBank database. |
There is no record. |