Summary | |
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Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00473 Corticotropin-releasing factor family |
Function |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. |
Biological Process |
GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007586 digestion GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009991 response to extracellular stimulus GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0052652 cyclic purine nucleotide metabolic process GO:0071496 cellular response to external stimulus GO:0072522 purine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005179 hormone activity GO:0042562 hormone binding GO:0051427 hormone receptor binding GO:0051428 peptide hormone receptor binding GO:0051429 corticotropin-releasing hormone receptor binding GO:0051431 corticotropin-releasing hormone receptor 2 binding GO:0071855 neuropeptide receptor binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UCN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UCN2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UCN2 in various data sets.
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Points in the above scatter plot represent the mutation difference of UCN2 in various data sets.
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Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UCN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UCN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UCN2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UCN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UCN2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UCN2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UCN2 |
Name | urocortin 2 |
Aliases | UCNI; SRP; UCN-II; prepro-urocortin 2; UR; stresscopin-related peptide; ucn II; urocortin II; urocortin-rela ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UCN2 collected from DrugBank database. |
There is no record. |