Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Multi-pass membrane protein |
Domain |
PF13506 Glycosyl transferase family 21 |
Function |
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". |
Biological Process |
GO:0006626 protein targeting to mitochondrion GO:0006643 membrane lipid metabolic process GO:0006664 glycolipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006672 ceramide metabolic process GO:0006677 glycosylceramide metabolic process GO:0006678 glucosylceramide metabolic process GO:0006679 glucosylceramide biosynthetic process GO:0006687 glycosphingolipid metabolic process GO:0006688 glycosphingolipid biosynthetic process GO:0006839 mitochondrial transport GO:0008544 epidermis development GO:0009247 glycolipid biosynthetic process GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0030148 sphingolipid biosynthetic process GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0046467 membrane lipid biosynthetic process GO:0046476 glycosylceramide biosynthetic process GO:0046513 ceramide biosynthetic process GO:0051222 positive regulation of protein transport GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:1903214 regulation of protein targeting to mitochondrion GO:1903509 liposaccharide metabolic process GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0008120 ceramide glucosyltransferase activity GO:0008194 UDP-glycosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0035251 UDP-glucosyltransferase activity GO:0046527 glucosyltransferase activity |
Cellular Component | - |
KEGG |
hsa00600 Sphingolipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1660662: Glycosphingolipid metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-428157: Sphingolipid metabolism |
Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UGCG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between UGCG and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UGCG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UGCG in various data sets.
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Points in the above scatter plot represent the mutation difference of UGCG in various data sets.
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Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGCG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGCG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGCG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGCG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UGCG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UGCG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UGCG |
Name | UDP-glucose ceramide glucosyltransferase |
Aliases | glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ...... |
Chromosomal Location | 9q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UGCG collected from DrugBank database. |
Details on drugs targeting UGCG.
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