Browse UGCG

Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Multi-pass membrane protein
Domain PF13506 Glycosyl transferase family 21
Function

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".

> Gene Ontology
 
Biological Process GO:0006626 protein targeting to mitochondrion
GO:0006643 membrane lipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006677 glycosylceramide metabolic process
GO:0006678 glucosylceramide metabolic process
GO:0006679 glucosylceramide biosynthetic process
GO:0006687 glycosphingolipid metabolic process
GO:0006688 glycosphingolipid biosynthetic process
GO:0006839 mitochondrial transport
GO:0008544 epidermis development
GO:0009247 glycolipid biosynthetic process
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0030148 sphingolipid biosynthetic process
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0046467 membrane lipid biosynthetic process
GO:0046476 glycosylceramide biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0051222 positive regulation of protein transport
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0090316 positive regulation of intracellular protein transport
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903509 liposaccharide metabolic process
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0008120 ceramide glucosyltransferase activity
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0035251 UDP-glucosyltransferase activity
GO:0046527 glucosyltransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00600 Sphingolipid metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1660662: Glycosphingolipid metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-428157: Sphingolipid metabolism
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UGCG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between UGCG and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
15958592GlioblastomaPromote immunityGangliosides were found to participate in the induction of T-cell apoptosis, because the glucosylceramide synthase inhibitor (PPPP) significantly reduced the abilities of all four apoptogenic lines to kill the lymphocytes.
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UGCG in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UGCG in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7590.0744
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.370.548
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3180.842
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0180.96
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0690.971
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0490.984
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0670.862
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4010.811
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.260.886
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1310.924
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5590.774
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2580.00384
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of UGCG in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGCG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGCG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGCG.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGCG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UGCG expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UGCG and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUGCG
NameUDP-glucose ceramide glucosyltransferase
Aliases glucosylceramide synthase; ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UGCG collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting UGCG.
ID Name Drug Type Targets #Targets
DB00419MiglustatSmall MoleculeUGCG1
DB09039EliglustatSmall MoleculeUGCG1