Summary | |
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Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum lumen Endoplasmic reticulum-Golgi intermediate compartment |
Domain |
PF06427 UDP-glucose |
Function |
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. |
Biological Process |
GO:0006011 UDP-glucose metabolic process GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0006515 misfolded or incompletely synthesized protein catabolic process GO:0006517 protein deglycosylation GO:0006986 response to unfolded protein GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009225 nucleotide-sugar metabolic process GO:0010498 proteasomal protein catabolic process GO:0018196 peptidyl-asparagine modification GO:0018279 protein N-linked glycosylation via asparagine GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030968 endoplasmic reticulum unfolded protein response GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036503 ERAD pathway GO:0036507 protein demannosylation GO:0036508 protein alpha-1,2-demannosylation GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043413 macromolecule glycosylation GO:0051084 'de novo' posttranslational protein folding GO:0051788 response to misfolded protein GO:0070085 glycosylation GO:0071218 cellular response to misfolded protein GO:0071712 ER-associated misfolded protein catabolic process GO:0097359 UDP-glucosylation GO:1904380 endoplasmic reticulum mannose trimming |
Molecular Function |
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity GO:0008194 UDP-glycosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0035251 UDP-glucosyltransferase activity GO:0046527 glucosyltransferase activity GO:0051082 unfolded protein binding |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0044322 endoplasmic reticulum quality control compartment |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-901042: Calnexin/calreticulin cycle R-HSA-901032: ER Quality Control Compartment (ERQC) R-HSA-392499: Metabolism of proteins R-HSA-532668: N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-597592: Post-translational protein modification |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UGGT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UGGT1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UGGT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of UGGT1 in various data sets.
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Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGGT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGGT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGGT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGGT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UGGT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UGGT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UGGT1 |
Name | UDP-glucose glycoprotein glucosyltransferase 1 |
Aliases | HUGT1; UGCGL1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1 |
Chromosomal Location | 2q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UGGT1 collected from DrugBank database. |
There is no record. |