Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF01704 UTP--glucose-1-phosphate uridylyltransferase |
Function |
Plays a central role as a glucosyl donor in cellular metabolic pathways. |
Biological Process |
GO:0000271 polysaccharide biosynthetic process GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0006011 UDP-glucose metabolic process GO:0006065 UDP-glucuronate biosynthetic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006112 energy reserve metabolic process GO:0009225 nucleotide-sugar metabolic process GO:0009226 nucleotide-sugar biosynthetic process GO:0009250 glucan biosynthetic process GO:0015980 energy derivation by oxidation of organic compounds GO:0016051 carbohydrate biosynthetic process GO:0019255 glucose 1-phosphate metabolic process GO:0033692 cellular polysaccharide biosynthetic process GO:0034637 cellular carbohydrate biosynthetic process GO:0044042 glucan metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0046398 UDP-glucuronate metabolic process |
Molecular Function |
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity GO:0005536 glucose binding GO:0016779 nucleotidyltransferase activity GO:0019103 pyrimidine nucleotide binding GO:0030246 carbohydrate binding GO:0032557 pyrimidine ribonucleotide binding GO:0048029 monosaccharide binding GO:0051748 UTP-monosaccharide-1-phosphate uridylyltransferase activity GO:0070569 uridylyltransferase activity |
Cellular Component | - |
KEGG |
hsa00040 Pentose and glucuronate interconversions hsa00052 Galactose metabolism hsa00500 Starch and sucrose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-173599: Formation of the active cofactor, UDP-glucuronate R-HSA-70326: Glucose metabolism R-HSA-156588: Glucuronidation R-HSA-3322077: Glycogen synthesis R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-156580: Phase II conjugation |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UGP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of UGP2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UGP2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of UGP2 in various data sets.
|
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UGP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UGP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UGP2 |
Name | UDP-glucose pyrophosphorylase 2 |
Aliases | UGPP1; UGP1; UDP-glucose pyrophosphorylase 1; UDPG; UDPGP; UDPGP2; UGPP2; pHC379; UDP-glucose diphosphorylas ...... |
Chromosomal Location | 2p14-p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UGP2 collected from DrugBank database. |
There is no record. |