Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Microsome membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein |
Domain |
PF00201 UDP-glucoronosyl and UDP-glucosyl transferase |
Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). |
Biological Process |
GO:0006063 uronic acid metabolic process GO:0008202 steroid metabolic process GO:0009812 flavonoid metabolic process GO:0009813 flavonoid biosynthetic process GO:0019585 glucuronate metabolic process GO:0052695 cellular glucuronidation GO:0052696 flavonoid glucuronidation |
Molecular Function |
GO:0008194 UDP-glycosyltransferase activity GO:0015020 glucuronosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups |
Cellular Component | - |
KEGG |
hsa00040 Pentose and glucuronate interconversions hsa00053 Ascorbate and aldarate metabolism hsa00140 Steroid hormone biosynthesis hsa00830 Retinol metabolism hsa00860 Porphyrin and chlorophyll metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 hsa00983 Drug metabolism - other enzymes hsa01100 Metabolic pathways |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-156588: Glucuronidation R-HSA-1430728: Metabolism R-HSA-156580: Phase II conjugation |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UGT2B17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UGT2B17 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UGT2B17 in various data sets.
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Points in the above scatter plot represent the mutation difference of UGT2B17 in various data sets.
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Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGT2B17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGT2B17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGT2B17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGT2B17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UGT2B17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UGT2B17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | UGT2B17 |
Name | UDP glucuronosyltransferase 2 family, polypeptide B17 |
Aliases | UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UGT2B17 collected from DrugBank database. |
There is no record. |