Browse UGT2B17

Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Microsome membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase
Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

> Gene Ontology
 
Biological Process GO:0006063 uronic acid metabolic process
GO:0008202 steroid metabolic process
GO:0009812 flavonoid metabolic process
GO:0009813 flavonoid biosynthetic process
GO:0019585 glucuronate metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
Molecular Function GO:0008194 UDP-glycosyltransferase activity
GO:0015020 glucuronosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00040 Pentose and glucuronate interconversions
hsa00053 Ascorbate and aldarate metabolism
hsa00140 Steroid hormone biosynthesis
hsa00830 Retinol metabolism
hsa00860 Porphyrin and chlorophyll metabolism
hsa00980 Metabolism of xenobiotics by cytochrome P450
hsa00982 Drug metabolism - cytochrome P450
hsa00983 Drug metabolism - other enzymes
hsa01100 Metabolic pathways
Reactome R-HSA-211859: Biological oxidations
R-HSA-156588: Glucuronidation
R-HSA-1430728: Metabolism
R-HSA-156580: Phase II conjugation
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UGT2B17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UGT2B17 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UGT2B17 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2410.385
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1340.812
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3240.518
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-3.5370.00953
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-3.8410.038
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-3.1860.136
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1550.278
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.1310.224
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0460.979
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5650.647
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5570.729
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.270.464
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of UGT2B17 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGT2B17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGT2B17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGT2B17.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGT2B17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UGT2B17 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UGT2B17 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUGT2B17
NameUDP glucuronosyltransferase 2 family, polypeptide B17
Aliases UDP glycosyltransferase 2 family, polypeptide B17; UDPGT2B17; C19-steroid-specific UDP-glucuronosyltransfera ......
Chromosomal Location4q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UGT2B17 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.