Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF00201 UDP-glucoronosyl and UDP-glucosyl transferase |
Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). |
Biological Process |
GO:0006063 uronic acid metabolic process GO:0009812 flavonoid metabolic process GO:0009813 flavonoid biosynthetic process GO:0019585 glucuronate metabolic process GO:0033594 response to hydroxyisoflavone GO:0033595 response to genistein GO:0052695 cellular glucuronidation GO:0052696 flavonoid glucuronidation GO:0071407 cellular response to organic cyclic compound GO:0071412 cellular response to genistein GO:0071413 cellular response to hydroxyisoflavone GO:0080184 response to phenylpropanoid GO:1901654 response to ketone GO:1901655 cellular response to ketone |
Molecular Function |
GO:0008194 UDP-glycosyltransferase activity GO:0015020 glucuronosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-156588: Glucuronidation R-HSA-1430728: Metabolism R-HSA-156580: Phase II conjugation |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UGT3A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of UGT3A2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UGT3A2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of UGT3A2 in various data sets.
|
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UGT3A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UGT3A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UGT3A2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UGT3A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UGT3A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UGT3A2 |
Name | UDP glycosyltransferase 3 family, polypeptide A2 |
Aliases | UDPGT 3A2; UDP-glucuronosyltransferase 3A2 |
Chromosomal Location | 5p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UGT3A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |