Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF00129 Class I Histocompatibility antigen |
Function |
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0019882 antigen processing and presentation GO:0030101 natural killer cell activation GO:0042267 natural killer cell mediated cytotoxicity |
Molecular Function |
GO:0003823 antigen binding GO:0046703 natural killer cell lectin-like receptor binding |
Cellular Component |
GO:0031225 anchored component of membrane GO:0046658 anchored component of plasma membrane |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ULBP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ULBP3 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ULBP3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ULBP3 in various data sets.
|
There is no record. |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ULBP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ULBP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ULBP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ULBP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ULBP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ULBP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ULBP3 |
Name | UL16 binding protein 3 |
Aliases | RAET1N; ALCAN-gamma; N2DL-3; NKG2DL3; UL16-binding protein 3; retinoic acid early transcript 1N; NKG2D ligan ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ULBP3 collected from DrugBank database. |
There is no record. |