Browse URI1

Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
Domain PF02996 Prefoldin subunit
Function

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0009615 response to virus
GO:0010921 regulation of phosphatase activity
GO:0010923 negative regulation of phosphatase activity
GO:0016049 cell growth
GO:0016311 dephosphorylation
GO:0035303 regulation of dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0048545 response to steroid hormone
GO:0051346 negative regulation of hydrolase activity
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004857 enzyme inhibitor activity
GO:0004864 protein phosphatase inhibitor activity
GO:0019208 phosphatase regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0019888 protein phosphatase regulator activity
GO:0051219 phosphoprotein binding
Cellular Component GO:0000428 DNA-directed RNA polymerase complex
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0030425 dendrite
GO:0030880 RNA polymerase complex
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between URI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of URI1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.58 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of URI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0830.615
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2070.921
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2950.847
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2190.389
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2040.927
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2370.934
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0680.861
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2010.913
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0810.968
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2150.877
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4610.831
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1860.035
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of URI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of URI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of URI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by URI1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of URI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of URI1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between URI1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolURI1
NameURI1, prefoldin-like chaperone
Aliases FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ......
Chromosomal Location19q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting URI1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.