Summary | |
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Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion. |
Domain |
PF02996 Prefoldin subunit |
Function |
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
Biological Process |
GO:0001558 regulation of cell growth GO:0009615 response to virus GO:0010921 regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0016049 cell growth GO:0016311 dephosphorylation GO:0035303 regulation of dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0048545 response to steroid hormone GO:0051346 negative regulation of hydrolase activity GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0097193 intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0004857 enzyme inhibitor activity GO:0004864 protein phosphatase inhibitor activity GO:0019208 phosphatase regulator activity GO:0019212 phosphatase inhibitor activity GO:0019888 protein phosphatase regulator activity GO:0051219 phosphoprotein binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005665 DNA-directed RNA polymerase II, core complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030425 dendrite GO:0030880 RNA polymerase complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between URI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of URI1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of URI1 in various data sets.
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Points in the above scatter plot represent the mutation difference of URI1 in various data sets.
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Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of URI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of URI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by URI1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of URI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of URI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between URI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | URI1 |
Name | URI1, prefoldin-like chaperone |
Aliases | FLJ10575; URI; PPP1R19; unconventional prefoldin RPB5 interactor; RPB5-mediating protein; protein phosphatas ...... |
Chromosomal Location | 19q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting URI1 collected from DrugBank database. |
There is no record. |