Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type IV membrane protein |
Domain |
PF09753 Membrane fusion protein Use1 |
Function |
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. |
Biological Process |
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0048193 Golgi vesicle transport |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04130 SNARE interactions in vesicular transport |
Reactome |
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between USE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between USE1 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of USE1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of USE1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of USE1 in various data sets.
|
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of USE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of USE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by USE1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of USE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of USE1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between USE1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | USE1 |
Name | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
Aliases | SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting USE1 collected from DrugBank database. |
There is no record. |