Browse USE1

Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Single-pass type IV membrane protein
Domain PF09753 Membrane fusion protein Use1
Function

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

> Gene Ontology
 
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007034 vacuolar transport
GO:0007041 lysosomal transport
GO:0048193 Golgi vesicle transport
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04130 SNARE interactions in vesicular transport
Reactome R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between USE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between USE1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24962571osteosarcomaPromote immunityD12 could react with PBF A2.2 peptide-pulsed T2 cells and HLA-A2+PBF+ osteosarcoma cell lines and simultaneously demonstrated that the HLA·peptide complex was expressed on osteosarcoma cells.
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of USE1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of USE1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2580.483
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6660.783
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0380.983
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.060.801
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0080.996
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1450.939
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1090.704
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2080.857
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0260.984
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.120.941
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0530.983
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0160.801
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of USE1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of USE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of USE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by USE1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of USE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of USE1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between USE1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUSE1
Nameunconventional SNARE in the ER 1 homolog (S. cerevisiae)
Aliases SLT1; MDS032; D12; Q-SNARE; SNARE-like tail-anchored protein 1 homolog (S. cerevisiae); SNARE-like tail-anch ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting USE1 collected from DrugBank database.
> Drugs from DrugBank database
 

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