Summary | |
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Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Early endosome Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). |
Domain |
PF07145 Ataxin-2 C-terminal region PF00443 Ubiquitin carboxyl-terminal hydrolase |
Function |
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). |
Biological Process |
GO:0000731 DNA synthesis involved in DNA repair GO:0006301 postreplication repair GO:0006914 autophagy GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0010506 regulation of autophagy GO:0016579 protein deubiquitination GO:0019985 translesion synthesis GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0042770 signal transduction in response to DNA damage GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0070555 response to interleukin-1 GO:0070646 protein modification by small protein removal GO:0071347 cellular response to interleukin-1 GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction |
Molecular Function |
GO:0002039 p53 binding GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0008234 cysteine-type peptidase activity GO:0019783 ubiquitin-like protein-specific protease activity GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0044325 ion channel binding GO:0101005 ubiquitinyl hydrolase activity |
Cellular Component |
GO:0005769 early endosome |
KEGG | - |
Reactome |
R-HSA-73893: DNA Damage Bypass R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5656169: Termination of translesion DNA synthesis R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-5689880: Ub-specific processing proteases |
Summary | |
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Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between USP10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of USP10 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of USP10 in various data sets.
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Points in the above scatter plot represent the mutation difference of USP10 in various data sets.
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Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of USP10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of USP10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by USP10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of USP10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of USP10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between USP10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | USP10 |
Name | ubiquitin specific peptidase 10 |
Aliases | UBPO; KIAA0190; ubiquitin specific protease 10; deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiqu ...... |
Chromosomal Location | 16q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting USP10 collected from DrugBank database. |
There is no record. |