Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Mitochondrion |
Domain |
PF06337 DUSP domain PF14836 Ubiquitin-like domain PF00443 Ubiquitin carboxyl-terminal hydrolase PF14533 Ubiquitin-specific protease C-terminal |
Function |
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). ; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. |
Biological Process |
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0016570 histone modification GO:0016578 histone deubiquitination GO:0016579 protein deubiquitination GO:0030509 BMP signaling pathway GO:0035520 monoubiquitinated protein deubiquitination GO:0035616 histone H2B conserved C-terminal lysine deubiquitination GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0070646 protein modification by small protein removal GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0008234 cysteine-type peptidase activity GO:0019783 ubiquitin-like protein-specific protease activity GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0042393 histone binding GO:0046332 SMAD binding GO:0061649 ubiquitinated histone binding GO:0101005 ubiquitinyl hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-2173788: Downregulation of TGF-beta receptor signaling R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173789: TGF-beta receptor signaling activates SMADs R-HSA-5689603: UCH proteinases R-HSA-5689880: Ub-specific processing proteases |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between USP15 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between USP15 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of USP15 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of USP15 in various data sets.
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Points in the above scatter plot represent the mutation difference of USP15 in various data sets.
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Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of USP15. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of USP15. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by USP15. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of USP15. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of USP15 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between USP15 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | USP15 |
Name | ubiquitin specific peptidase 15 |
Aliases | KIAA0529; UNPH4; ubiquitin specific protease 15; UNPH-2; deubiquitinating enzyme 15; ubiquitin thioesterase ...... |
Chromosomal Location | 12q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting USP15 collected from DrugBank database. |
There is no record. |